Why are LABAs contraindicated in acute asthma attacks?

Long-acting beta-agonists (LABAs) are designed for the long-term management of asthma and are not suitable for use in acute asthma attacks. This is because LABAs have a delayed onset of action compared to short-acting beta-agonists (SABAs), which are formulated to provide quick relief from acute bronchospasm. LABAs work by relaxing the airway muscles over an extended period, but this gradual action means they do not provide immediate relief during an exacerbation when rapid bronchodilation is necessary.

Using LABAs in an acute attack can lead to poor management of the situation since they do not act quickly enough to alleviate symptoms, which can be detrimental. Therefore, they are typically prescribed in conjunction with inhaled corticosteroids for long-term control, but should not be used as a rescue medication during sudden onset of asthma symptoms. This distinction is crucial for effective asthma management.