Which side effect is commonly associated with long-term steroid therapy?

Long-term steroid therapy is indeed commonly associated with osteoporosis. Corticosteroids, such as prednisone, can lead to decreased bone density by reducing calcium absorption in the intestines, increasing calcium excretion from the kidneys, and inhibiting the activity of the osteoblasts, which are the cells responsible for bone formation. The cumulative effects of long-term steroid use can result in significant bone loss, putting patients at a higher risk for fractures and developing osteoporosis.

Osteoporosis is a serious side effect that healthcare providers monitor closely in patients undergoing prolonged steroid treatment. Steps to mitigate this risk may include calcium and vitamin D supplementation, weight-bearing exercises, and in some cases, medications specifically designed to strengthen bone density. Given the serious nature of osteoporosis, it is critical for patients on long-term steroid therapy to be aware of this risk and engage in preventive measures.