Which of the following is NOT a pathophysiological effect of inflammation in asthma?

In asthma, inflammation leads to several pathophysiological effects that contribute to the symptoms experienced by patients. Hyper-reactive airways, bronchoconstriction, and increased mucus production are all key components of the inflammatory response in this condition.

Hyper-reactive airways refer to the heightened sensitivity of the airways to various stimuli, which can trigger an exaggerated bronchoconstrictor response. This is a fundamental aspect of asthma, making airways more susceptible to constriction in response to allergens, irritants, or even exercise.

Bronchoconstriction is a hallmark of asthma as well, occurring due to the contraction of smooth muscles surrounding the airways in response to inflammatory mediators. This narrowing of the airways significantly impairs airflow and leads to the characteristic symptoms of wheezing, coughing, and difficulty breathing.

Mucus production is another direct consequence of airway inflammation in asthma. The increased secretion of mucus can lead to airway obstruction, further complicating airflow and exacerbating symptoms.

On the other hand, increased airway diameter is not an effect of inflammation in asthma. In fact, asthma leads to a decrease in airway diameter due to bronchoconstriction and inflammation, not an increase. This understanding of the pathophysiology of asthma is