Which condition is more likely to develop as a side effect of prolonged steroid use?

Prolonged use of corticosteroids can lead to several metabolic and physiological changes in the body, one of which is hypertension. Corticosteroids, particularly when used in high doses or for extended periods, can cause fluid retention, increased blood volume, and alterations in the distribution of electrolytes, including sodium and potassium. This can result in elevated blood pressure, commonly recognized as hypertension.

In contrast, hypoglycemia, diarrhea, and fatigue are less commonly associated with prolonged steroid use. While steroids can cause hyperglycemia due to their effect on glucose metabolism, hypoglycemia is more likely associated with insulin use or other medications. Diarrhea is not a prevalent side effect of steroid therapy; instead, corticosteroids can often lead to gastrointestinal issues such as ulcers or constipation. Fatigue may occur, but it is not a direct result of steroid use and is typically more related to other underlying health conditions or the effects of the disease being treated.

Thus, the propensity for the development of hypertension makes it the most likely condition to emerge as a side effect from prolonged steroid therapy.