When weaning from Nitric Oxide, what is the expected reduction sequence?

The expected reduction sequence when weaning from Nitric Oxide involves gradual decreases in the concentration to minimize the risk of rebound pulmonary hypertension and ensure patient safety. Starting at a higher concentration such as 20 parts per million (ppm) and systematically reducing it to lower concentrations like 10, 5, and finally reaching 1-2 ppm allows for a careful tapering process.

This methodical decrease helps evaluate the patient's response to lower levels of the gas, which is crucial for determining the appropriate rate of weaning based on the individual’s clinical status. The final step to 1-2 ppm serves as a precautionary measure, ensuring that there is residual therapeutic effect while reducing the risks associated with abrupt cessation of treatment.

In contrast, the other sequences presented do not reflect the typical clinical approach to weaning from Nitric Oxide, which emphasizes controlled, incremental reductions to assess the patient's tolerance and response more effectively.