What is the typical dose range for administering Nitric Oxide?

Nitric oxide is often used as a pulmonary vasodilator in clinical settings, particularly for conditions such as pulmonary hypertension in newborns. The typical dosing range for nitric oxide administration is crucial for maximizing benefits while minimizing potential toxicity.

The correct answer, which indicates a dose range of 2-20 ppm (parts per million), is based on established clinical guidelines for the use of inhaled nitric oxide. Within this range, lower concentrations (around 2-5 ppm) are typically effective for infants, especially those with persistent pulmonary hypertension, while higher doses may be utilized in specific situations under careful monitoring.

This dosing range is integral as it balances effectiveness in improving oxygenation and reducing pulmonary artery pressure, while also avoiding adverse effects that can arise from excessive nitric oxide concentrations. Concentrations exceeding this range can lead to increased levels of nitrogen dioxide, a toxic byproduct.

In clinical practice, it is vital to stay within this established range to ensure patient safety and therapeutic efficacy.