Klebsiella is primarily treated with which class of antibiotics?

Klebsiella infections are primarily treated with fluoroquinolones because this class of antibiotics has a broad spectrum of activity that is effective against many Gram-negative bacteria, including Klebsiella species. Fluoroquinolones disrupt bacterial DNA replication by inhibiting DNA gyrase and topoisomerase IV, which are crucial for bacterial cell division and survival.

Klebsiella is known for its resistance patterns, and while some strains may be susceptible to other antibiotic classes, fluoroquinolones are often preferred in empirical therapy for serious infections due to their effectiveness and good bioavailability. They can penetrate well into tissues, making them suitable for treating serious infections associated with Klebsiella.

The other classes mentioned have varying effectiveness or are not the first line of treatment for Klebsiella. Tetracyclines have limitations due to resistance and are not reliable for serious infections. Aminoglycosides may be used in combination therapy but are typically not the primary choice due to nephrotoxicity and their need for therapeutic monitoring. Macrolides have limited effect against Gram-negative bacteria like Klebsiella and are primarily used for treating atypical infections or respiratory pathogens such as Streptococcus.